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oai:figshare.com:article/32995025 2026-05-01T00:00:00Z portal_693 item_type_8 month_year_05_2026

Assessment of SDOH And AL Impact on Breast and Prostate Cancer Mortality Himanshu Sharma (141539) Disparities around Breast and Prostate Cancer Mortality This dissertation examines how Social Determinants of Health (SDOH) become biologically embodied through allostatic load (AL) and influence breast and prostate cancer severity. Using electronic health record data, geocoded neighborhood disadvantage measures, and longitudinal biomarker profiles, I operationalized multi-subsystem AL (cardiovascular, metabolic, immune, neuroendocrine) across multiple pre-diagnosis time points.These findings advance informatics methods for integrating social and physiologic data and highlight chronic stress biology as a potential pathway underlying cancer disparities. 2026-05-01T00:00:00Z Text Thesis 10.25417/uic.32995025.v1 https://figshare.com/articles/thesis/Assessment_of_SDOH_And_AL_Impact_on_Breast_and_Prostate_Cancer_Mortality/32995025 In Copyright Open Access after 2028-05-01