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Deciphering mechanisms underlying vascular cell pathophysiology in malaria retinopathy Shannon McDonnell (5107253) PUREID: 670312994 Cerebral Malaria malaria retinopathy endothelial dysfunction Cerebral malaria (CM) is a severe encephalopathy caused by sequestration of Plasmodium-infected red blood cells in the brain, leading to neurological complications and high mortality in children. Malarial retinopathy (MR) is often observed in CM and serves as a diagnostic marker. In a murine model of CM induced by <em>Plasmodium berghei</em> ANKA, we used fundus imaging, Optical Coherence Tomography and fluorescein angiography to examine retinal changes and performed single-cell and spatial transcriptomic analyses to investigate molecular alterations associated with disease. This integrative approach highlights the murine model as a useful platform for studying neurovascular pathology in CM.<br><i><br>Thesis is embargoed until 31 July 2027.</i> 2026-10-01T16:09:41Z Text Thesis 10.17034/32826236.v1 https://figshare.com/articles/thesis/Deciphering_mechanisms_underlying_vascular_cell_pathophysiology_in_malaria_retinopathy/32826236 All Rights Reserved Open Access after 2027-07-31