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oai:figshare.com:article/32826215 2026-10-01T16:09:52Z portal_1172 item_type_8 month_year_10_2026

Eutectic systems embedded within implantable matrices for improved postsurgical wound management and recovery Magdy Mahmoud Abdelquader (24304481) PUREID: 668052799 THEDES deep eutectic solvent implant drug release lidocaine Flurbiprofen NSAIDs polymer thermal analysis FTIR IVIVC biorelevant physical testing Therapeutic deep eutectic solvents (THEDES) are emerging drug-enabling systems that offer improved stability and biopharmaceutical performance over conventional amorphous formulations. This thesis systematically investigate<br>THEDES from fundamental principles to clinical translation for post-surgical drug delivery.<br>Mechanistic studies elucidated the role of hydrogen bonding, glass-forming ability, and composition in THEDES formation and stability, while revealing a thermodynamically preferred "THEDES point." Polymer compatibility was examined leading to practical formulation guidelines and a novel thermal quantification method. These insights enabled successful incorporation of THEDES into implantable polymeric matrices with tunable mechanical and release properties. A biorelevant simulated peritoneal fluid was also developed to enhance in vitro-in vivo correlation.<br><br><i>Thesis embargoed until 31st July 2031</i> 2026-10-01T16:09:52Z Text Thesis 10.17034/32826215.v1 https://figshare.com/articles/thesis/Eutectic_systems_embedded_within_implantable_matrices_for_improved_postsurgical_wound_management_and_recovery/32826215 All Rights Reserved Open Access after 2031-07-31