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oai:figshare.com:article/32826179 2026-10-01T16:10:16Z portal_1172 item_type_8 month_year_10_2026

Development and characterisation of hybrid triblock copolymeric nanomicelles for ocular drug delivery Ahmad A. Assiri (24304445) PUREID: 661370712 Block copolymer micelles hybrid triblock copolymers nanomicelles nanomicelles; ocular drug delivery curcumin mucoadhesion corneal penetration sustained drug release mPEG-PLGA-mPEG bPEI-PLGA-bPEI encapsulation efficiency nanocarriers bioavailability anti-inflammatory therapy in vitro and ex vivo evaluation <p>This thesis investigates the development of positively charged, mucoadhesive hybrid triblock copolymer nanomicelles as an innovative ocular drug delivery system aimed at enhancing the stability, solubility, and corneal retention of curcumin for anti-inflammatory therapy. Amphiphilic copolymers were synthesized to form nanoscale micellar structures capable of sustained drug release and improved ocular bioavailability. The nanomicelles exhibited favorable physicochemical properties, high encapsulation efficiency, and stability, along with excellent biocompatibility and ocular tolerability. In vitro, ex vivo, and imaging studies confirmed enhanced corneal penetration and targeted interaction with inflamed ocular tissues, supporting their potential to address key limitations of conventional ocular formulations. Overall, the findings underscore hybrid triblock copolymeric nanomicelles as a promising and scalable platform for effective ocular drug delivery with prolonged therapeutic action and reduced systemic exposure.</p><br><i>Thesis is embargoed until 31 Dec 2028.</i><br> 2026-10-01T16:10:16Z Text Thesis 10.17034/32826179.v1 https://figshare.com/articles/thesis/Development_and_characterisation_of_hybrid_triblock_copolymeric_nanomicelles_for_ocular_drug_delivery/32826179 All Rights Reserved Open Access after 2028-12-31