2026-10-14T08:38:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32805068 2026-10-01T16:18:39Z portal_1172 item_type_8 month_year_10_2026

Early detection of late anthracycline induced cardiotoxicity in survivors of childhood malignancy Claire Louise McCune (24292013) PUREID: 660365559 Anthracycline cardiotoxicity late cardiotoxicity cardio-oncology Anthracycline chemotherapy has transformed childhood cancer survival but confers a lifelong risk of late cardiotoxicity. Current surveillance detects dysfunction only at relatively advanced stages, and improved circulating biomarkers are needed for earlier identification.This study assessed cardiovascular health and biomarker profiles in adult survivors of childhood cancer previously exposed to anthracyclines. A comprehensive clinical and imaging evaluation was performed, and an exploratory discovery phase using proteomic and microRNA analyses identified potential circulating candidates for further investigation.Survivors demonstrated a substantial burden of cardiovascular risk factors and high rates of subclinical cardiac dysfunction. Established biomarkers had limited discriminative value, while several emerging candidates showed meaningful associations with imaging measures of cardiac function.These findings highlight the potential role of novel circulating biomarkers in improving early detection of late anthracycline cardiotoxicity and support the need for prospective validation.<br><br>Thesis is embargoed until 31 December 2030. 2026-10-01T16:18:39Z Text Thesis 10.17034/32805068.v1 https://figshare.com/articles/thesis/Early_detection_of_late_anthracycline_induced_cardiotoxicity_in_survivors_of_childhood_malignancy/32805068 All Rights Reserved Open Access after 2030-12-31