2026-10-14T07:00:57Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32736761 2026-09-30T09:49:16Z category_24748 portal_984 item_type_3 month_year_09_2026

Source data - The identity gene Fezf2 is repurposed postnatally to specify inhibitory input in an activity-dependent manner. Tim Kroon (22627511) Beatriz Rico (20769989) Neurosciences not elsewhere classified Neuroscience Activity-dependent brain development Synaptic inhibition <p dir="ltr">The development and function of cortical circuits require an appropriate balance of excitation and inhibition. Pyramidal cells recruit inhibitory synapses in proportion to their activity, but it is unclear whether pyramidal cell subtypes use distinct mechanisms to acquire cell-type specific levels of inhibition. Here, we show that a neuronal identity gene is repurposed to regulate inhibitory connectivity. Fezf2, a transcription factor that establishes the identity of extratelencephalic pyramidal cells in layer 5 during embryonic development, is regulated by activity after birth only in those neurons. Activity-dependent Fezf2 controls the number of inhibitory synapses formed by parvalbumin-expressing interneurons through regulation of the cell-surface protein Cadherin-22. Our findings reveal a mechanism for cell-type specificity within activity-dependent circuit development through the redeployment of genes that establish neuronal subtype identity.</p> 2026-09-30T09:49:16Z Dataset Dataset 10.18742/32736761.v2 https://figshare.com/articles/dataset/Kroon_et_al_2026/32736761 CC BY