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oai:figshare.com:article/32641875 2026-10-01T16:20:05Z portal_1172 item_type_8 month_year_10_2026

Formulation strategies for modifying drug release from preformed solid implants Elizabeth Magill (13159279) PUREID: 657740024 Implantable device medical device drug delivery pharmaceutical technology pharmacy 3D printing formulation controlled release Long-acting implantable drug delivery devices offer a means to overcoming current challenges within pharmacy such as pill fatigue, poor adherence to medication, low oral bioavailability, and dose-limiting side effects. Controlling drug release from such devices, however, remains a central challenge to their clinical translation. Accordingly, this thesis presents strategies to modulate and predict drug release from biodegradable solid implants. <br><br>Three model compounds were used throughout this thesis, carvedilol (CAR), amitriptyline hydrochloride (AMT), and risperidone (RIS). An analytical method was developed and validated for each compound according to the International Council for Harmonisation (ICH) guideline Q2 R2. <br><br>Subsequently, three experimental chapters were developed outlining various methods of drug release modifications to solid-formed implantable devices.<br><br><i>Thesis is embargoed until 31 December 2030.</i> 2026-10-01T16:20:05Z Text Thesis 10.17034/32641875.v1 https://figshare.com/articles/thesis/Formulation_strategies_for_modifying_drug_release_from_preformed_solid_implants/32641875 All Rights Reserved Open Access after 2030-12-31