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oai:figshare.com:article/32641461 2026-10-01T16:23:16Z portal_1172 item_type_8 month_year_10_2026

The role of SorLA in B cell antigen trafficking and immune responses Adam Nathan McShane (16794736) PUREID: 644174898 SorLA B cell antigen trafficking humoral immune responses High-affinity humoral responses to infection and vaccination critically relies on the ability of B cells to capture and process antigen for presentation to cognate CD4+ T cells. However, the molecular composition of B cell endocytic and intracellular trafficking pathways remains poorly understood. In this thesis I present the first account of intracellular trafficking receptor, SorLA, in immunity. Together, my results provide novel evidence of SorLA’s interaction with the BCR, role in BCR uptake, downstream BCR-antigen trafficking to proteolytic lysosomes and peptide-MHC II presentation, and in modulation of immune responses in vivo. <br><br><i>Thesis is embargoed until 31 December 2028.</i> 2026-10-01T16:23:16Z Text Thesis 10.17034/32641461.v1 https://figshare.com/articles/thesis/The_role_of_SorLA_in_B_cell_antigen_trafficking_and_immune_responses/32641461 All Rights Reserved Open Access after 2028-12-31