2026-10-07T18:33:16Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32641329 2026-10-01T16:24:04Z portal_1172 item_type_8 month_year_10_2026

Development and evaluation of microneedles for ocular drug delivery Katie Glover (24169932) PUREID: 642260186 microneedles ocular drug delivery biomechanics sclera This PhD research tackles the challenge of drug delivery to the posterior eye, where current methods often cause discomfort, side effects, and limited efficacy. The study explores a novel, minimally invasive approach using a single hollow microneedle for targeted and sustained ocular delivery. Scleral biomechanics were characterised using uniaxial testing and advanced imaging to guide microneedle optimisation. Safe insertion forces and accurate penetration depths were achieved using ex vivo porcine sclera, supported by a whole-eye model that monitored intraocular pressure in real time. A 3D cohesive zone finite element model simulated insertion mechanics. To enhance drug retention, formulation strategies were explored, showing that higher viscosity and particle size improved scleral retention. A nanosuspension of axitinib was developed for intrascleral retention, with safety confirmed via cytotoxicity testing and HET-CAM assay. This work establishes a promising intrascleral delivery platform and provides a strong foundation for future clinical translation.<br><br><i>Thesis embargoed until 31st July 2030.</i> 2026-10-01T16:24:04Z Text Thesis 10.17034/32641329.v1 https://figshare.com/articles/thesis/Development_and_evaluation_of_microneedles_for_ocular_drug_delivery/32641329 All Rights Reserved Open Access after 2030-07-31