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oai:figshare.com:article/32641200 2026-10-01T16:25:09Z portal_1172 item_type_8 month_year_10_2026

Scaling ‘down’ microwave-assisted in situ amorphisation for personalisation of paediatric formulations Meng Zhang (154027) PUREID: 640457132 Amorphous solid dispersion (ASD) microwave-induced in situ amorphisation mini tablets deformation paediatric therapy oral administration This thesis demonstrates that microwave-induced in situ amorphisation is a promising method for formulating paediatric mini tablets containing poorly water-soluble drugs. It investigated the effects of tablet size and weight, addressed deformation issues, and provided mechanistic insight into the use of salt-based systems. The findings highlight the potential of this approach to improve drug solubility and stability, offering a novel pathway for personalised paediatric drug delivery.<br><br><i>Thesis is embargoed until 31 July 2030.</i> 2026-10-01T16:25:09Z Text Thesis 10.17034/32641200.v1 https://figshare.com/articles/thesis/Scaling_down_microwave-assisted_in_situ_amorphisation_for_personalisation_of_paediatric_formulations/32641200 All Rights Reserved Open Access after 2030-07-31