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oai:figshare.com:article/32639274 2026-10-01T16:41:13Z portal_1172 item_type_8 month_year_10_2026

Sustainable microfluidic production of lipid-based nanoformulations for the delivery of biologics and small molecules Edward Weaver (6638648) PUREID: 568808892 Microfluidics biologics Lipid Nanoparticle The emerging technology of microfluidics is used here in this thesis to encapsulate both biologic and small molecule active pharmaceutical ingredients within lipid-based nanoformulations. A focus on the use of additive manufacturing for the fabrication of microfluidic devices is given, with analysis into the effect of device parameters on the properties of the final nanoformulation. Using these principles, a bottom-up approach is taken, to succesfully produce formulations ranging from a simple bilayer drug delivery system, to more complex solid lipid nan particles and protein-conjugated nanovessels. Throughout this thesis, a particular focus on the sustainable use of emerging technologies is discussed, with the hope of bettering and prolonging their wide-scale use.<br><br><i>Thesis is embargoed until 31 July 2029.</i> 2026-10-01T16:41:13Z Text Thesis 10.17034/32639274.v1 https://figshare.com/articles/thesis/Sustainable_microfluidic_production_of_lipid-based_nanoformulations_for_the_delivery_of_biologics_and_small_molecules/32639274 All Rights Reserved Open Access after 2029-07-31