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oai:figshare.com:article/32639211 2026-10-01T16:41:40Z portal_1172 item_type_8 month_year_10_2026

Porous amine-based polymers and iron oxide nano particles incorporated with photoresponsive N(S)-nitroso or hydroresponsive N-diazeniumdiolate functional groups for antimicrobial nitric oxide delivery Yusheng Qiu (789887) PUREID: 562318312 Nitric oxide drug delivery N-diazeniumdiolate iron oxide nanoparticles porous organic polymers Nitric oxide (NO) plays diverse roles in human physiology; however, storing NO chemically and controlling its release poses significant challenges. Despite studies on various low molecular weight NO donors like S-nitrosothiol, N-nitrosamine, and N-diazeniumdiolate having been reported, their limited NO storage capacity and poor stability have impeded their clinical applicability. In this thesis, our primary aim was to explore the potential of porous organic polymers (POPs) for storing and releasing exogenous nitric oxide in a controlled manner for medical applications. Several series of POPs containing secondary amine groups (-NH-) were synthesised based on the monomer 2,4,6-tris-(chloromethyl)-mesitylene (TCM) with diamines and the monomer melamine (MA) with aldehydes. These polymers were modified through nitrosation or diazeniumdiolation reactions, resulting in porous N-nitroso polymers (PNPs) or N-diazeniumdiolate polymers (PDPs), respectively. NO was stored in the polymers in the forms of N-nitroso and N-diazeniumdiolate functionalities. The PNPs exhibited strong stability in various inorganic and organic solutions, with no detection of nitrosamine leakage. In this study, most polymers demonstrated significant NO storage capacity (~ 0.01 – 7.14 mmol/g) and the ability to release a substantial amount of NO ( ~0.01 – 2.15 mmol/g) in a controllable manner. The relationship between structures (especially the chemical structure and porous structures) and NO-releasing performances was mainly discussed. It has been demonstrated that POPs can be used to create new nitric oxide-releasing materials for medical applications.<br><br><i>Thesis is embargoed until 31 July 2027.</i><br><br> 2026-10-01T16:41:40Z Text Thesis 10.17034/32639211.v1 https://figshare.com/articles/thesis/Porous_amine-based_polymers_and_iron_oxide_nano_particles_incorporated_with_photoresponsive_N_S_-nitroso_or_hydroresponsive_N-diazeniumdiolate_functional_groups_for_antimicrobial_nitric_oxide_delivery/32639211 All Rights Reserved Open Access after 2027-07-31