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Polymorph control during continuous manufacturing Philip Michael Lynch (24168333) PUREID: 548136192 Polymorphism multivariate analysis This project aimed to demonstrate a controlled process for polymorph conversion which could be operated on a continuous basis. Both monotropic and enantiotropic polymorphic systems were investigated, with the process required for the monotropic Forms I and II of Hydrochlorothiazide proving unsuitable for continuous manufacturing due to long hold times and a requirement for minimal agitation.<br><br>For the enantiotropic Forms III and I of Carbamazepine, a twin screw extrusion process was developed further and paired with quantification of of the polymorphic composition. This system was able to operate at a steady state, while maintaining real-time data collection on the composition of the extruded powders.<br><br><i>Thesis is embargoed until 31 July 2027.</i> 2026-10-01T16:43:32Z Text Thesis 10.17034/32638983.v1 https://figshare.com/articles/thesis/Polymorph_control_during_continuous_manufacturing/32638983 All Rights Reserved Open Access after 2027-07-31