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oai:figshare.com:article/32638743 2026-10-01T16:45:47Z portal_1172 item_type_8 month_year_10_2026

Identification and bioactivity study of a naturally-occurring peptide, Brevinin-2LK, from the skin secretion of the frog, Limnonectes kuhlii Mengyuan Shen (5123603) PUREID: 528561575 antimicrobial peptide biological activity Antimicrobial peptides (AMPs) derived from amphibian sources have been extensively studied and utilized as models for investigating the mechanisms and potential applications of peptide-based anti-infectious medications. In this work, using the technology of ‘shotgun’ cloning, an AMP was identified and characterised from Limnonectes kuhlii skin secretion and named Brevinin-2LK. The functional selectivity of Brevinin-2LK (LK) was investigated by using in vitro assays, including antibacterial, haemolytic, and anticancer tests. <br><br><i>Thesis is embargoed until 31 December 2028</i>. 2026-10-01T16:45:47Z Text Thesis 10.17034/32638743.v1 https://figshare.com/articles/thesis/Identification_and_bioactivity_study_of_a_naturally-occurring_peptide_Brevinin-2LK_from_the_skin_secretion_of_the_frog_Limnonectes_kuhlii/32638743 All Rights Reserved Open Access after 2028-12-31