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oai:figshare.com:article/32638539 2026-10-01T16:46:08Z portal_1172 item_type_8 month_year_10_2026

Identification and activity assessment of a bioactive peptide QUB-1460 from the skinsecretion of the Northeast Forest Frog (Rana dybowskii) Qiangwei Li (2939178) PUREID: 527689799 Antimicrobial peptides immune system bacteria Cytotoxicity natural products Antibiotic resistance, leading to increased treatment failures and substantial economic burdens, poses a significant threat to modern medicine's advancement. Antimicrobial peptides (AMPs), because of their primary action mechanism of disrupting bacterial membrane integrity, offer a promising solution to counteract the limitations of conventional antibiotics due to a reduced potential for resistance induction. AMPs, especially positively-charged, alpha-helical, amphipathic polypeptides found in amphibian skin secretions, have various physiological and pharmacological activities. This research led to the discovery of an antimicrobial peptide, QUB-1460, in the skin secretions of Rana dybowskii.<br><br><i>Thesis embargoed until 31st December 2028</i> 2026-10-01T16:46:08Z Text Thesis 10.17034/32638539.v1 https://figshare.com/articles/thesis/Identification_and_activity_assessment_of_a_bioactive_peptide_QUB-1460_from_the_skinsecretion_of_the_Northeast_Forest_Frog_Rana_dybowskii_/32638539 All Rights Reserved Open Access after 2028-12-31