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oai:figshare.com:article/32633574 2026-10-01T17:01:59Z portal_1172 item_type_8 month_year_10_2026

Characterisation of cystic fibrosis airway-associated proteases in the era of CFTR modulation Zhixuan Yang (20778562) PUREID: 382400109 cystic fibrosis CFTR epithelial sodium channel inflammation infection Cystic fibrosis (CF) is a hereditary disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The lung disease is, however, also associated with dysregulation of the epithelial sodium channel (ENaC) which leads to dehydrated airways predisposing the individual to chronic cycles of infection and inflammation. ENaC is activated by trypsin-like channel activating proteases (TLPs), inhibition of which increases airway surface liquid volume and improves mucociliary function of primary human airway epithelial cells (hAECs) grown at air-liquid interface (ALI).<br><br><i>Thesis is embargoed until 31 December 2027</i>. 2026-10-01T17:01:59Z Text Thesis 10.17034/32633574.v1 https://figshare.com/articles/thesis/Characterisation_of_cystic_fibrosis_airway-associated_proteases_in_the_era_of_CFTR_modulation/32633574 All Rights Reserved Open Access after 2027-12-31