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oai:figshare.com:article/32633379 2026-10-01T17:03:46Z portal_1172 item_type_8 month_year_10_2026

Investigation into the effects of fatty acids in the diet of swine on immune response and the gut microbiome Robyn McKenna (24165621) PUREID: 368306876 fatty acids weaning microbiome antimicrobial resistance pigs rotavirus Previously, in-feed antibiotics were used to enhance performance gains and counteract adverse effects of weaning. However; an EU-wide ban prohibiting the use of antibiotic growth promoters was issued in 2006, prompting the search for safe and innovative alternatives. Studies have indicated that dietary fatty acids can minimise weaning disorders including elevated incidence of enteric disease and immunodepression. Furthermore, research has indicated that including fatty acids in the porcine diet has a positive effect on performance; increasing growth rate and enhancing feed conversion. It is thought these health and production benefits come from an immunomodulatory role of the fatty acids, however; the mechanisms through which these changes occur are not well understood. <br><br>The aim of this research was to collaborate with local feed industry in order to produce relevant information regarding the use of fatty acids as a swine health supplement and alternative to growth-promoting antibiotics. To do this, a combination of in vitro assays and field studies were used to investigate the immunomodulatory and anti-viral properties of a unique blend of fatty acids. Additionally, deep sequencing and metagenomic methods were employed to explicitly explore the influence fatty acid supplementation has on shaping the intestinal microbial community during the weaning period. Results indicate that fatty acids had a positive influence on pif performance, they also acted to initiate and enhance immune response to infection in vitro. Dietary fatty acids played a role in modifying the intestinal microflora, establishing an environment that favours the growth of commensal species such as Lactobacillus. The fatty acid blend also demonstrated anti-viral activity against porcine rotavirus in vitro.<br> 2026-10-01T17:03:46Z Text Thesis 10.17034/32633379.v1 https://figshare.com/articles/thesis/Investigation_into_the_effects_of_fatty_acids_in_the_diet_of_swine_on_immune_response_and_the_gut_microbiome/32633379 All Rights Reserved