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oai:figshare.com:article/32633367 2026-10-01T17:03:53Z portal_1172 item_type_8 month_year_10_2026

QUB-2592, a novel peptide discovered in Rana pipiens with potent antimicrobial and anticancer activities Wenxin He (632402) PUREID: 366094290 Potential alternative to antibiotics antimicrobial peptide Brevinin-1 peptide Rana Pipiens anti-proliferation activity Due to the increasing incidence of antibiotic-resistant bacterial infections, antimicrobial peptides (AMPs) have begun to engender interest as potential efficacious substitutes. In this study, a novel antimicrobial peptide, QUB-2592, was identified in the skin secretion of Rana pipiens using a ‘Shotgun’ cloning strategy. QUB-2592 showed potent antimicrobial activity and could kill S. aureus at 4 µM, E. coli at 8 µM and C. albicans at 16 µM. At bactericidal concentrations, QUB-2592 showed low haemolysis activity on horse red blood cells with a HC_50 value of 60.76 µM, which indicated the safety of the peptide. Meanwhile, QUB-2592 exhibited obvious anticancer activity on human non-small lung cancer cell line, H838, with a IC_50 value of 11.29 µM. The identification and functional study of QUB-2592 provided useful experience for later research on brevinin-1 type peptides. Also, QUB-2592 might be used as a promising agent to treat diseases induced by drug resistant pathogen infection and cancer.<br><br><i>Thesis is embargoed until 31 December 2027</i>. 2026-10-01T17:03:53Z Text Thesis 10.17034/32633367.v1 https://figshare.com/articles/thesis/QUB-2592_a_novel_peptide_discovered_in_Rana_pipiens_with_potent_antimicrobial_and_anticancer_activities/32633367 All Rights Reserved Open Access after 2027-12-31