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oai:figshare.com:article/32633334 2026-10-01T17:04:11Z portal_1172 item_type_8 month_year_10_2026

Lignin-Based Infection-Resistant Biomaterials Zili Ji (24165600) PUREID: 365373749 Antimicrobial polymers lignin This research is an initial attempt to incorporate lignin as a leaching antibacterial substance within biomedical materials to reduce device-associated infections. Lignin-loaded poly(2-hydroxyethyl methacrylate)-co-poly(methacrylic acid) hydrogels were synthesised, while tetracycline hydrochloride (TET) was also loaded into the polymers for comparison. Synthesised hydrogels were validated with suitable drug releasing and loading abilities, desirable pH-sensitive characteristics as well as surface properties, and improved thermal stabilities. <br><br>After verifying the antimicrobial abilities of lignin, materials have been tested under both normal and infected urine conditions against urinary pathogens S. aureus (Gram-positive) and P. mirabilis (Gram-negative) to investigate their ability to reduce catheter associated urinary tract infections. Lignin-loaded copolymers demonstrated similar antibacterial properties to TET-loaded copolymers by significantly decreasing relative bacterial adherence and reducing the planktonic cell density to below the LOD when incubated with S. aureus. Lignin-loaded hydrogels were more effective in inhibiting the growth of S. aureus compared to P. mirabilis in adherence tests, while lignin-loaded copolymers showed mixed results after incubation with P. mirabilis. Generated results of microbiological studies revealed the potential of lignin-loaded polymers for use as urinary catheter coating materials due to their anti-bacterial properties. <br><br>Lignin-loaded hydrogels have shown intrinsic desirable characteristics, antibacterial properties, and great potential to be considered as promising candidates for use as anti-infective coating materials with limited possibility of leading to bacterial resistance. 2026-10-01T17:04:11Z Text Thesis 10.17034/32633334.v1 https://figshare.com/articles/thesis/Lignin-Based_Infection-Resistant_Biomaterials/32633334 All Rights Reserved