2026-10-14T16:51:25Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32631540 2026-10-01T17:19:05Z portal_1172 item_type_8 month_year_10_2026

Mechanochemical preparation of multi-component pharmaceutical materials for enhanced physicochemical properties Alice Moffett-Culkin (24164478) PUREID: 242938786 Mechanochemistry hot-melt extrusion eutectic multi-component pharmaceutical materials therapeutic deep eutectic salt reactive extrusion multivariate analysis An extremely large volume of new chemical entities, as well as existing active pharmaceutical ingredients (APIs), on the market, possess sub-optimal physicochemical properties; particularly, their solubility. The synthesis of multi-component pharmaceutical systems, including the lesser-studied eutectic and liquid systems, pose as approaches with which to improve the physicochemical properties of these APIs. Currently, one of the biggest development hurdles associated with multi-component systems, and in particular liquid systems, is their intermediate handling. Consequently, this research aims to use a continuous manufacturing technique, hot-melt extrusion (HME), to manufacture multi-component systems while removing their intermediate handling.<br><br><i>Thesis embargoed until 31 December 2026</i>. 2026-10-01T17:19:05Z Text Thesis 10.17034/32631540.v1 https://figshare.com/articles/thesis/Mechanochemical_preparation_of_multi-component_pharmaceutical_materials_for_enhanced_physicochemical_properties/32631540 All Rights Reserved Open Access after 2026-12-31