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oai:figshare.com:article/32631534 2026-10-01T17:19:08Z portal_1172 item_type_8 month_year_10_2026

Fused deposition modelling three-dimensional printing of solid dosage forms Sinmisola A. Oladeji (24164472) PUREID: 242864825 3D printing Fused deposition modelling (FDM) gastric floating sustained release zero-order release rheology oral solid dosage forms fixed dose combinations Three-dimensional printing (3DP) is a widely used technique for the design and manufacture of complex solid dosage forms with the objective of formulating personalized medicines and on-demand manufacturing. Among commercially available models, fused deposition modelling 3D-printing (FDM-3DP) has shown the potential to fabricate objects with various internal structures and the ability to introduce multiple specific functionalities. This thesis’s main aim was to understand printability in FDM-3DP and the factors influencing it, as well as to manufacture novel gastro-retentive floating drug delivery systems through FDM-3DP using pharmaceutical excipients. Hot-melt extrusion (HME) was implemented to fabricate filaments with adequate properties for FDM-3DP. Rheological, mechanical and physical characterisation of filaments were evaluated to provide information on the impact of these properties on the FDM 3DP process. Theophylline-loaded filaments, suitable for FDM-3DP, were successfully formulated using three polymeric carriers (Polyvinyl alcohol (PVA), Hydroxypropyl Cellulose (HPC), and Soluplus®). FDM-3DP enabled the manufacture of monolithic and non-monolithic floating drug delivery systems using a sandwich design. The tablet design showed the ability to achieve prolonged gastric floating (12 hours) with no floating lag time. Formulations containing Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical excipients with tailored drug release profiles.<br><br><i>Thesis embargoed until 31 December 2026</i>.<br> 2026-10-01T17:19:08Z Text Thesis 10.17034/32631534.v1 https://figshare.com/articles/thesis/Fused_deposition_modelling_three-dimensional_printing_of_solid_dosage_forms/32631534 All Rights Reserved Open Access after 2026-12-31