2026-10-08T18:12:17Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32320017 2026-09-28T04:49:59Z category_24367 category_24625 category_24616 item_type_3 month_year_09_2026

Supporting data for "Human metapneumovirus reprograms macrophage function toward a hybrid antiviral-regulatory state and remodels exosome biology" Karissa Chávez (23927583) Matías Moraga-Astete (23928277) Sebastián A. Echeverría-Araya (23928685) Alison Sepúlveda-Pontigo (23927621) Felipe R. Uribe (23927624) Matías Montecinos (23927626) Grabiel J García-Velázquez (23928688) Felipe Melo-Gonzalez (17892068) Katina Schinnerling (6742502) Claudio Cabello-Verrugio (548364) Abel E. Vasquez (11779928) Claudia A. Riedel (7372613) Susan M. Bueno (7372616) Alexis M. Kalergis (7426883) Karen Bohmwald (9284118) Jorge Soto (23928516) Virology Innate immunity Cellular immunology bone marrow-derived macrophages (BMDM) Human metapneumovirus macrophages polarization Exosomes Viral infection Innate response <p dir="ltr">This repository contains the raw datasets, images, and associated analyses generated in this study evaluating the effect of human metapneumovirus (hMPV) infection on bone marrow-derived macrophages (BMDMs). The repository includes the underlying data associated with both the main and supplementary figures presented in the manuscript. The deposited materials include Excel files containing flow cytometry analyses of BMDMs infected with hMPV (MOI 5) at 24, 48, 72, 96, and 120 hours post-infection, as well as analyses of macrophages treated with conditioned supernatants obtained from hMPV-infected LET-1 cells across a similar infection time course. The repository also includes RT-qPCR datasets associated with hMPV N gene expression and datasets related to extracellular vesicle and exosome characterization, including transmission electron microscopy (TEM) images, NanoSight nanoparticle tracking analyses, and flow cytometry data. Raw images and experimental data supporting the supplementary analyses are also provided.</p><p dir="ltr">Together, these datasets support the findings regarding macrophage phenotypic reprogramming, antiviral responses, and extracellular vesicle-associated changes induced by hMPV infection.</p> 2026-09-28T04:49:59Z Dataset Dataset 10.6084/m9.figshare.32320017.v5 https://figshare.com/articles/dataset/Human_metapneumovirus_reprograms_macrophage_function_toward_a_hybrid_antiviral-regulatory_state_and_remodels_exosome_biology_/32320017 CC BY 4.0