2026-10-14T14:03:10Z https://api.figshare.com/v2/oai

oai:figshare.com:article/32274384 2026-09-18T10:44:31Z category_24655 item_type_3 month_year_09_2026

Comparative proteomic analysis of the prefrontal cortex, hypothalamus, and hippocampus in mice model of affective disorders Disc1-Q31L-/- (Q31L) and wild-type mice L. Smirnova (22845794) K. Smirnova (22845795) A. Seregin (22845799) E. Dmitrieva (22845796) M. Zavyalova (22845797) A. Brzhovskiy (22845798) E. Ermakov (24287192) T. Amstislavskaya (22845802) Medical biochemistry - proteins and peptides (incl. medical proteomics) proteomics affective disorders brain tissue Disc1-Q31L-/- (Q31L) mice mice model of affective disorders <p dir="ltr">The pathogenesis of affective disorders, which are on the rise worldwide, remains poorly understood. Mutations in the human DISC1 gene are one of the main risk factors of affective disorders. This study, for the first time, evaluates the proteomic composition of the most relevant structures: the prefrontal cortex, hippocampus, and hypothalamus in the Disc1-Q31L-/- (Q31L) mouse model of affective disorders. Mass spectrometry was conducted and unique proteome of each brain area were annotated using “Panther GO database”. In Q31L cortex and hippocampus showed decrease in immunity related proteins, processes and molecular functions, whereas proteins involved in RNA-related processes were opverrepresented. Also 39 unique signaling pathways, were identified in the prefrontal cortex, 22 specific signaling pathways, primarily affecting the neurotransmitter and neuroendocrine systems in the hippocampus, and 38 hypothalamic signaling pathways, including those involved in immune and inflammatory responses, oxi-dative stress, neurotransmitter synthesis, and vesicular transport. Thus, over 1,000 unique proteins were identified in the brain of a mouse model of affective disorders, the study of which will help understand the mechanisms underlying the pathogenesis of affective disorders.</p> 2026-09-18T10:44:31Z Dataset Dataset 10.6084/m9.figshare.32274384.v4 https://figshare.com/articles/dataset/Proteomic_features_of_the_brain_structures_in_mice_model_of_affective_disorders_Disc1-Q31L-_-_Q31L_/32274384 CC BY 4.0