2026-05-06T01:25:41Z https://api.figshare.com/v2/oai

oai:figshare.com:article/31431553 2026-03-05T13:00:47Z category_26275 category_26278 portal_549 item_type_3 month_year_03_2026

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Claire L. Walsh Ferrara, Joseph D. Joseph D. Ferrara Olivo, Alessandro Alessandro Olivo Biomedical imaging Biomedical instrumentation X-ray phase-contrast CT X-ray dark field imaging X-ray microscopy 3D virtual histology cell imaging 2026-03-05 2026-03-05 Dataset 2026 University College London Three-dimensional analysis of biological tissue is crucial for linking tissue morphology to cellular function. While conventional histology remains the gold standard for visualising tissue architecture at subcellular resolution, it is limited by its destructive, two-dimensional nature and anisotropic resolution, hindering its use in capturing full three-dimensional representations of tissue volumes. Here, we demonstrate that phase-contrast X-ray microscopy enables non-destructive, three-dimensional virtual histology of unstained liver tissue with subcellular resolution. By automatically detecting cells’ nuclei over three-dimensional tissue volumes and quantifying relevant parameters (e.g. electron density, nuclear morphology), this instrument has the potential to provide novel capabilities in biomedicine linking volumetric tissue architecture with cell-scale quantification.

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