2026-10-14T09:46:04Z https://api.figshare.com/v2/oai

oai:figshare.com:article/31049650 2026-09-25T10:58:10Z category_4 category_7 category_8 category_12 category_13 category_14 category_16 category_19 category_873 category_46 category_734 category_61 category_62 category_64 category_106 portal_87 item_type_3 month_year_09_2026

Research on the effects and mechanisms of the Yiqi Huoxue Recipe in improving renal injury in diabetic nephropathy through the HIF-1 pathway Wen-Di Niu (22989988) Hao-Wei Liang (22989991) Lue Hong (20390618) Jin-Xing He (22989994) Jia-Hui Qian (22989997) Fei Pan (255667) Zhi-Wei Xu (2422396) Hui Wang (30400) Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Physiology Pharmacology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Developmental Biology Marine Biology Cancer Science Policy Yiqi Huoxue Recipe diabetic nephropathy HIF-1 signaling pathway liquid chromatography-mass spectrometry network pharmacology <p>This study investigates the therapeutic effects and mechanisms of the Yiqi Huoxue Recipe (YHR) on renal injury in Diabetic nephropathy (DN). Through mass spectrometry analysis, animal experiments, and network pharmacology approaches, it was found that YHR can ameliorate renal function indicators and pathological changes in DN rats, and reduce cell apoptosis. Mechanistic studies indicate that YHR alleviates hyperglycemia-induced renal inflammation and damage by inhibiting the HIF-1 signaling pathway, thereby improving DN.</p> 2026-01-12T16:05:39Z Dataset Dataset 10.6084/m9.figshare.31049650.v2 https://figshare.com/articles/dataset/Research_on_the_effects_and_mechanisms_of_the_Yiqi_Huoxue_Recipe_in_improving_renal_injury_in_diabetic_nephropathy_through_the_HIF-1_pathway/31049650 CC BY 4.0