The dataset enumerates all theoretically possible FUS peptide fragments derived from predicted enzymatic and chemical cleavage sites. For each fragment, biochemical and biophysical properties are calculated, enabling peptide-level analysis suitable for proteomics, biomarker discovery, and computational biology workflows. The present release includes the wild-type FUS sequence, with a framework designed for straightforward expansion to disease-associated mutations, including amyotrophic lateral sclerosis (ALS)-linked variants.

All data are provided in structured CSV format alongside a fully reproducible Python workflow and accompanying documentation. This repository is intended to support research into neurodegenerative disease mechanisms, RNA-binding protein biology, autoimmunity, peptide-antibody interactions, and machine-learning-based analyses. The FUS Degradome Foundation Atlas complements existing degradome resources and contributes to a systematic understanding of protein fragmentation in health and disease.