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oai:figshare.com:article/30426328 2025-08-01T00:00:00Z portal_693 item_type_8 month_year_08_2025

Conjugation of Zwitterionic and Cationic Peptides to Lipid and Polymer for Gene Delivery Yiqing Yang (775314) Gene delivery This dissertation focuses on the new materials that we established by the chemical conjugation between the peptides and the corresponding backbones. In total, we focus on 3 types of conjugates mainly. They are the zwitterionic peptide (EK)x pair lipid DSPE conjugates, THE DSPE-(EK)x, the cationic ionizable peptide RxHy lipid DSPE conjugates, the DSPE-RxHyC, and the cationic ionizable peptide RxHyC polysaccharide sugar mannan conjugates, the RxHyC-mannan. Such three different conjugates focus on different functionalities, with predesigned peptide sequences and the backbone to achieve desired results for siRNA delivery. 2025-08-01T00:00:00Z Text Thesis 10.25417/uic.30426328.v1 https://figshare.com/articles/thesis/Conjugation_of_Zwitterionic_and_Cationic_Peptides_to_Lipid_and_Polymer_for_Gene_Delivery/30426328 In Copyright Open Access after 2027-09-01