Simonas Griesius1*, Amy Richardson1, Marion Mercier1, Dimitri M Kullmann1*
1 Department of Epilepsy, UCL Queen Square Institute of Neurology,
University College London, London, WC1N 3BG, United Kingdom
*Corresponding author
Correspondance: s.griesius@ucl.ac.uk or d.kullmann@ucl.ac.uk
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Repository contains ex vivo data (LTP induction, backpropagating action potentials and dendritic calcium fluorescence)
Repository also contains files necessary to recreate the simulations used in the paper.
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Install the NEURON simulation environment.
Compile the .mod and .hoc files
Run the Jupyter notebooks.
Notes books may have key lines of code at the top that can be comment and uncomment
to specify important simulations settings - such as presence or absence of induced somatic
action potential spikes or synaptic input.
Notebooks:
asynch_and_nearsynch_uncaging_simulation.ipynb - fig 1, 2, 7
tbs_ltp.ipynb - fig 4
somatic_action_potential_spikes_and_synaptic_input_dendrite_26.ipynb - fig 5
stdp_calcium.ipynb - fig 7, 8
ngf_iclamp_step - fig 1
heatmap_plot.ipynb - reads a .csv to make heatmaps used in the paper.
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