2026-07-21T05:54:20Z https://api.figshare.com/v2/oai

oai:figshare.com:article/29489774 2025-07-07T10:21:01Z category_25210 category_25213 portal_549 item_type_3 month_year_07_2025

10.5522/04/29489774.v1 https://figshare.com/articles/dataset/Analytical_data_for_b_Nickel-Catalyzed_Cross-Coupling_of_Aryl_Chlorides_by_Heated_Mechanochemistry_Scalable_Suzuki-Miyaura_Reactions_via_Twin-Screw_Extrusion_b_/29489774 https://ndownloader.figshare.com/files/56024693 https://ndownloader.figshare.com/files/56024696 https://ndownloader.figshare.com/files/56024699 https://ndownloader.figshare.com/files/56024702 https://ndownloader.figshare.com/files/56024705 https://ndownloader.figshare.com/files/56024708 https://ndownloader.figshare.com/files/56024711 https://ndownloader.figshare.com/files/56024714 https://ndownloader.figshare.com/files/56024720 https://ndownloader.figshare.com/files/56024717 https://ndownloader.figshare.com/files/56024726 https://ndownloader.figshare.com/files/56024729 https://ndownloader.figshare.com/files/56024735 https://ndownloader.figshare.com/files/56024738 https://ndownloader.figshare.com/files/56024741 https://ndownloader.figshare.com/files/56024744 https://ndownloader.figshare.com/files/56024759 https://ndownloader.figshare.com/files/56024765 https://ndownloader.figshare.com/files/56024762 https://ndownloader.figshare.com/files/56024768 https://ndownloader.figshare.com/files/56024753 https://ndownloader.figshare.com/files/56024747 https://ndownloader.figshare.com/files/56024756 https://ndownloader.figshare.com/files/56024750 https://ndownloader.figshare.com/files/56024771 https://ndownloader.figshare.com/files/56024780 https://ndownloader.figshare.com/files/56024777 https://ndownloader.figshare.com/files/56024774 https://ndownloader.figshare.com/files/56024783 https://ndownloader.figshare.com/files/56024789 https://ndownloader.figshare.com/files/56024792 https://ndownloader.figshare.com/files/56024795 Raby Buck, Sarah Sarah Raby Buck Browne, Duncan L. Duncan L. Browne 0000-0002-8604-229X Ingram, Katherine Katherine Ingram Mattioli, Renan Rodini Renan Rodini Mattioli 0000-0001-5952-1941 Pastre, Julio Julio Pastre 0000-0001-9972-425X Bolt, Robert Robert Bolt Organic chemical synthesis Organic green chemistry Mechanochemistry Nickel catalysed Suzuki-Miyaura cross coupling Reactive Extrusion cross-coupling nickel catalysis twin-screw extrusion aryl chlorides 2025-07-07 2025-07-07 Dataset 2025 University College London The direct use of aryl chlorides in Suzuki–Miyaura cross-coupling remains a long-standing challenge due to the inert nature of the C–Cl bond. Herein, we report the first nickel-catalyzed Suzuki–Miyaura cross-coupling of aryl chlorides under solvent-minimized, heated mechanochemical conditions. Employing liquid-assisted grinding (LAG) and thermal input, a broad range of electron-deficient and electron-rich aryl chlorides were successfully coupled with aryl boronic acids in under 1 hour. The methodology was translated to a twin-screw extrusion (TSE) process, enabling continuous production at scales up to 400 mmol and 65 g isolated product. This work demonstrates a sustainable, scalable strategy for C–C bond formation using readily available feedstocks, highlighting the synergy between nickel catalysis, mechanochemistry, and continuous flow processing.

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