2026-07-06T08:14:45Z https://api.figshare.com/v2/oai

oai:figshare.com:article/26770204 2026-03-20T11:33:47Z category_24175 portal_549 item_type_3 month_year_03_2026

10.5522/04/26770204.v1 https://figshare.com/articles/dataset/_b_The_cytoplasm_of_living_cells_can_sustain_transient_and_steady_intracellular_pressure_gradients_b_/26770204 https://ndownloader.figshare.com/files/62971768 https://ndownloader.figshare.com/files/62971771 https://ndownloader.figshare.com/files/62971774 https://ndownloader.figshare.com/files/62971777 https://ndownloader.figshare.com/files/62971780 https://ndownloader.figshare.com/files/62971783 https://ndownloader.figshare.com/files/62971786 https://ndownloader.figshare.com/files/62971789 https://ndownloader.figshare.com/files/62971792 https://ndownloader.figshare.com/files/62971795 Charras, Guillaume Guillaume Charras Malboubi, Majid Majid Malboubi Esteki, Mohammad Hadi Mohammad Hadi Esteki Vaghela, Malti Malti Vaghela IT Korsak, Lulu Lulu IT Korsak 0000-0001-7662-3448 Petrie, Ryan J Ryan J Petrie 0000-0001-9780-4969 Moeendarbary, Emad Emad Moeendarbary Systems biology Cytoplasm Cytoskeleton Poroelasticity Membrane permeability 2026-03-20 2026-03-20 Dataset 2026 University College London Understanding how cells change shape dynamically under the influence of external and internal forces requires characterisation of the mechanical response of the cytoplasm, the viscous material that fills their interior. The cytoplasm consists of a porous solid phase bathed in a fluid, the cytosol. As the cytoplasm is incompressible, any cellular shape change necessitates redistribution of the cytosol within the cell and its flow rate sets the time-scale for deformation. How the cytoplasmic mechanical response affects cell physiology remains poorly understood. We show that the unique physical properties of the cytoplasm allow cells to sustain cellular-scale pressure gradients over minute time-scales. As a consequence, pressure-driven mechanisms may play a much greater role in cell physiology than currently appreciated.

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