2026-08-16T07:14:27Z https://api.figshare.com/v2/oai
oai:figshare.com:article/25689378 2024-05-13T16:08:53Z category_24736 category_24742 category_24733 category_24730 category_24196 category_24205 category_24208 category_24160 category_25258 category_29755 portal_549 item_type_3 month_year_05_2024
10.5522/04/25689378.v1 https://figshare.com/articles/dataset/Neurofilament_Degradome_Atlas_NDA_/25689378 https://ndownloader.figshare.com/files/45851487 https://ndownloader.figshare.com/files/46300996 https://ndownloader.figshare.com/files/46301017 10.1111/jnc.70023 Petzold, Axel Axel Petzold 0000-0002-0344-9749 <![CDATA[Neurofilament Degradome Atlas (NDA)]]> Computational neuroscience (incl. mathematical neuroscience and theoretical neuroscience) Peripheral nervous system Central nervous system Cellular nervous system Proteomics and metabolomics Translational and applied bioinformatics Bioinformatics and computational biology not elsewhere classified Proteomics and intermolecular interactions (excl. medical proteomics) Computational chemistry Biological mathematics Degradome Biomarker Neurofilament NfL NfM NfH INA Peripherin PRPH Internexin alpha Motor Neuron Disease Amyotrophic lateral sclerosis MND ALS Parkinson disease PD Charcot-Marie-Tooth diseases CMT Neurofilament inclusion body disease Protein aggregation 2024-05-13 2025-07-09 Dataset 2024 University College London (I) A compressed ASCII encoded archive (NDA-all-datasets.tar.gz) which contains 5 datasets:

  1. The Neurofilament Degradome Atlas (NDA-dataset.txt): this is the basic dataset for the NDA. This is an ASCII, tab delimited, text file. The dataset contains the NDA IDs with their peptide sequences, protein properties calculated for ready use. All Neurofilament Degradome Atlas IDs reviewed in the validation study are tagged to the respective PRIDE repositories.
  2. NDA_self_matches: all self-matches in the NDA by BLAST+.
  3. NDA_non_self_matches: all non-self matches of the NDA with the SwissProt database.
  4. The unique NDA sequences for HSP.
  5. The unique NDA sequences for PD.

(II) A compressed archive (NDA-codes-python.tar.gz) which contains the phyton codes for creation of the NDA from the FASTA sequences for each of the 5 Nf isoforms: NfH, NfM, NfL, INA, PRP.


Reference:
Petzold A. Proteolysis-Based Biomarker Repertoire of the Neurofilament Proteome. J Neurochem. 2025 Mar;169(3):e70023. doi: 10.1111/jnc.70023. PMID: 40066701; PMCID: PMC11894590.

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