2026-10-15T11:37:18Z https://api.figshare.com/v2/oai

oai:figshare.com:article/23592270 2025-01-29T08:24:34Z category_24784 portal_803 item_type_3 month_year_01_2025

Single-cell multimodal sequencing data from: Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases Hanna Thorsson (16460157) Rasmus Henningsson (735130) Noelia Puente-Moncada (780943) Ludvig Sjöström (20535230) Helena Ågerstam (4509814) Pablo Peña-Martínez (20234664) Carl Sandén (20535231) Marianne Rissler (4509826) Anders Castor (18890032) Hanne Vibeke Marquart (7299167) Signe Modvig (468240) Kajsa Paulsson (204593) Cornelis Jan Pronk (3159933) Kjeld Schmiegelow (3633592) Axel Hyrenius Wittsten (2152483) Christina Orsmark-Pietras (11155593) Henrik Lilljebjörn (7134941) Thoas Fioretos (32938) Cancer genetics BCP-ALL single-cell data <p dir="ltr">This dataset contains single-cell multimodal data (scRNA-, scBCR-, and scADT-seq) for twenty-three cases of childhood BCP-ALL, including four samples each of BCR::ABL1-positive, ETV6::RUNX1-positive, and HeH, together with eleven samples of DUX4-rearranged ALL. In addition, the datset contains 9 samples of mononuclear cells, sorted CD34+ (n=3), CD19+ (n=3), and unsorted (n=3), from five normal bone marrow from healthy donors. The dataset is available as raw sequencing reads (fastq; restricted access) or as an annotated multimodal dataset (h5ad). Cells from bone marrow were used for single-cell library preparation, according to the manufacturer’s protocol (10X Genomics CG000208: Chromium Next GEM Single Cell V(D)J Reagent Kits v1.1). The libaries were sequenced on a Novaseq 6000.</p> 2025-01-29T08:24:34Z Dataset Dataset 10.17044/scilifelab.23592270.v1 https://figshare.com/articles/dataset/Single-cell_multimodal_sequencing_data_from_Single-cell_genomics_details_the_maturation_block_in_BCP-ALL_and_identifies_therapeutic_vulnerabilities_in_DUX4-r_cases/23592270 CC BY-NC-ND 4.0