2026-10-13T14:58:34Z https://api.figshare.com/v2/oai

oai:figshare.com:article/22874480 2026-09-20T02:44:54Z category_24706 item_type_3 month_year_09_2026

<b>Gut flora-derived metabolites mediate protective effect of high fermentable fiber against placental inflammation in gestational diabetes mellitus</b> shuangbo huangs (15528239) Medical microbiology not elsewhere classified Gut flora high fermentable fiber placental inflammation gestational diabetes mellitus <p dir="ltr">Inflammation-associated insulin resistance is a key trigger of gestational diabetes mellitus (GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we report the association of placental inflammation (tumor necrosis factor-α) and abnormal maternal glucose metabolism in GDM patients, and a high fermentable dietary fiber (HFDF, <i>Konjac</i>) could reduce GDM development through gut microbiota-short-chain fatty acids-placental inflammation axis in GDM mice model. Mechanistically, HFDF increases abundances of <i>Lachnospiraceae</i> and butyrate, reduces placental-derived inflammation by enhancing gut barrier and inhibiting the transfer of bacterial-derived lipopolysaccharide, and ultimately resists high fat diet-induced insulin resistance. Butyrate abundances in placentae of GDM patients and mice are negatively correlated with placental TNF-α. Moreover, <i>Lachnospiraceae</i> and butyrate have similar anti-GDM and anti-placental inflammation effects. These findings demonstrate the involvement of important placental inflammation-related mechanisms in the progression of GDM and the great potential of HFDFs to reduce susceptibility to GDM through gut-microbiota-placenta axis.</p> 2026-09-20T02:44:54Z Dataset Dataset 10.6084/m9.figshare.22874480.v5 https://figshare.com/articles/dataset/_strong_Gut_flora-derived_metabolites_mediate_protective_effect_of_high_fermentable_fiber_against_placental_inflammation_in_gestational_diabetes_mellitus_strong_/22874480 CC BY 4.0