2026-05-07T16:08:37Z https://api.figshare.com/v2/oai
oai:figshare.com:article/20867117 2022-11-04T00:10:06Z category_24748 portal_549 item_type_3 month_year_11_2022
10.5522/04/20867117.v1 https://figshare.com/articles/dataset/Raw_Data_for_On-demand_cell-autonomous_gene_therapy_for_brain_circuit_disorders_Qiu_et_al_2022_Science/20867117 https://ndownloader.figshare.com/files/37130714 https://ndownloader.figshare.com/files/37130762 https://ndownloader.figshare.com/files/37131104 https://ndownloader.figshare.com/files/37131394 https://ndownloader.figshare.com/files/37131434 https://ndownloader.figshare.com/files/37132133 https://ndownloader.figshare.com/files/37132601 https://ndownloader.figshare.com/files/37132702 https://ndownloader.figshare.com/files/37132952 https://ndownloader.figshare.com/files/37133312 https://ndownloader.figshare.com/files/37133359 10.1126/science.abq6656 Lignani, Gabriele Gabriele Lignani O'Neill, Nathanael Nathanael O'Neill 0000-0002-4137-4629 Qiu, Yichen Yichen Qiu Maffei, Benito Benito Maffei Zourray, Clara Clara Zourray <![CDATA[Raw Data for "On-demand cell-autonomous gene therapy for brain circuit disorders", Qiu et al. 2022 Science]]> Neurosciences not elsewhere classified gene therapy effectiveness epilepsy assembloids MEA EEG data IEGs Potassium channels Neuroscience 2022-10-27 2023-06-01 Dataset 2022 University College London Raw Data for Qui et al. 2022 10.1126/science.abq6656


On-demand cell-autonomous gene therapy for brain circuit disorders

Yichen Qiu, Nathanael O’Neill, Benito Maffei, Clara Zourray, Amanda Almacellas Barbanoj, Jenna C. Carpenter,Steffan P. Jones, Marco Leite, Thomas J. Turner, Francisco C. Moreira, Albert Snowball, Tawfeeq Shekh-Ahmad, Vincent Magloire, Serena Barral, Manju A. Kurian, Matthew C. Walker, Stephanie Schorge, Dimitri M. Kullmann, Gabriele Lignani


Content:

EEG 

MEA

Immuno

Patch Clamp Electrophysiology


All data are in a open source format. MEA files can be analysed using the MATLAB-based developed by Prof Michela Chiappalone and requests should be direct to:

Michela Chiappalone michela.chiappalone@unige.it

Ilaria Colombi Ilaria.Colombi@iit.it


EEG files are .zip with different transmitters. See EEG_Keys.xlxs for whcih virus was used in each animal.


MEA files are divided in 2 separate .zip: 1. Fig2 and Fig S3 and S7. 2. Fig S6.


Immuno: all the raw images are in the .zip file seprated by Figure #


Patch Clamp Electrophysiology: all the raw .abf files are in the .zip file separated by Figure #


For more info or to request materials please contact the corrsponding author Gabriele Lignani g.lignani@ucl.ac.uk



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