2026-06-01T16:39:39Z https://api.figshare.com/v2/oai
oai:figshare.com:article/19650552 2022-04-25T13:58:35Z category_24400 category_30331 category_24748 portal_549 item_type_2 month_year_04_2022
10.5522/04/19650552.v1 https://figshare.com/articles/media/Postnatal_video_recordings_spinal_Tor1a_d-cko_mice_develop_early_onset_generalised_torsional_dystonia/19650552 https://ndownloader.figshare.com/files/39400577 https://ndownloader.figshare.com/files/39400586 https://ndownloader.figshare.com/files/39400595 https://ndownloader.figshare.com/files/39400604 https://ndownloader.figshare.com/files/39400610 https://ndownloader.figshare.com/files/39400625 https://ndownloader.figshare.com/files/39400631 Pocratsky, Amanda Amanda Pocratsky Do Nascimento Xavier Fernandes, Filipe Filipe Do Nascimento Xavier Fernandes Ozyurt, Gorkem Gorkem Ozyurt White, Ian Ian White Sullivan, Roisin Roisin Sullivan O'Callaghan, Benjamin Benjamin O'Callaghan Smith, Calvin Calvin Smith Surana, Sunaina Sunaina Surana Beato, Marco Marco Beato Brownstone, Rob Rob Brownstone <![CDATA[Postnatal video recordings: spinal Tor1a d-cko mice develop early onset generalised torsional dystonia]]> Animal behaviour Behavioural neuroscience Neurosciences not elsewhere classified Movement disorder Dystonia Mouse model Animal Behaviour Behavioral Neuroscience Neuroscience DYT1 spinal cord 2023-03-27 2023-03-27 Media 2022 University College London Supplemental movies of the dystonic-like phenotype in spinal Tor1a d-cko mice associated with Pocratsky et al 2023, Science Translational Medicine


Videos were generated throughout postnatal development from litterate controls (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. 


Pocratsky2023_MovieS1: Representative postnatal video recordings of littermate control (#1161022) vs spinal Tor1a d-cko (#1161023) showing onset and progression of dystonic-like signs over postnatal maturation.  


Pocratsky2023_MovieS2: Tail suspension-induced paw clasping and clenching in spinal Tor1a d-cko mice. 


Pocratsky2023_MovieS3: Range of discoordinated limb movements observed in pre-weaned spinal Tor1a d-cko mice.


Pocratsky2023_MovieS4: Range of trunk torsion and instability observed throughout postnatal maturation in spinal Tor1a d-cko mice.


Pocratsky2023_MovieS5: Range of abnormal postures observed at rest and during voluntary movements in spinal Tor1a d-cko mice.


Pocratsky2023_MovieS6: Intrusion of tremulous-like phenotype in spinal Tor1a d-cko mice. 


Pocratsky2023_MovieS7: Longitudinal postnatal video recordings from littermate control (Avil-wt/wt;Tor1a-wt/flox) and dorsal root ganglia (DRG)-specific Tor1a d-cko (Avil-wt/cre;Tor1a-flox/flox)


Full methodological detail can be found in manuscript.


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