2026-06-01T16:55:42Z https://api.figshare.com/v2/oai
oai:figshare.com:article/19649871 2023-03-27T14:24:15Z category_24748 portal_549 item_type_3 month_year_03_2023
10.5522/04/19649871.v1 https://figshare.com/articles/dataset/Intracellular_spinal_recordings_patch-clamp_and_dorsal_root_evoked_excitatory_post-synaptic_currents/19649871 https://ndownloader.figshare.com/files/34894500 https://ndownloader.figshare.com/files/34894518 https://ndownloader.figshare.com/files/34894521 Pocratsky, Amanda Amanda Pocratsky Do Nascimento Xavier Fernandes, Filipe Filipe Do Nascimento Xavier Fernandes Ozyurt, Gorkem Gorkem Ozyurt White, Ian Ian White Sullivan, Roisin Roisin Sullivan O'Callaghan, Benjamin Benjamin O'Callaghan Smith, Calvin Calvin Smith Surana, Sunaina Sunaina Surana Beato, Marco Marco Beato Brownstone, Rob Rob Brownstone <![CDATA[Intracellular spinal recordings: patch-clamp and dorsal root evoked excitatory post-synaptic currents]]> Neurosciences not elsewhere classified Electrophysiology Spinal cord Motoneurons Neuroscience movement disorder dystonia DYT1 2023-03-27 2023-03-27 Dataset 2023 University College London Intracellular recording dataset from spinal motoneurons associated with Pocratsky et al 2023, Science Translational Medicine


Data generated from isolated postnatal spinal cord preparations with dorsal roots attached (postnatal day 1-13). Groups: littermate controls (Cdx2::wt;Tor1a-wt/frt) and spinal Tor1a d-cko mice (Cdx2::FlpO;Tor1a-frt/frt) that develop early onset generalised torsional dystonia. 


Intracellular_recordings.xlsx - dataset: intrinsic lumbar spinal motoneuron properties and dorsal root-evoked excitatory post-synaptic currents (EPSCs)


210616_DIC_lumbarMNs_P9-control.nd2: differential interference contract (DIC) image of lumbar motoneuron pool in control mouse


210616_DIC_lumbarMNs_P9-spinalTor1aCKO.nd2: DIC image of lumbar motoneuron pool in spinal Tor1a d-cko mouse


Full methodological detail can be found in manuscript


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