2026-05-07T09:09:59Z https://api.figshare.com/v2/oai
oai:figshare.com:article/19369376 2022-10-26T08:45:49Z category_24121 portal_549 item_type_3 month_year_10_2022
10.5522/04/19369376.v1 https://figshare.com/articles/dataset/An_oral_pH-responsive_Streptococcus_agalactiae_vaccine_formulation_provides_protective_immunity_to_pathogen_challenge_in_tilapia/19369376 https://ndownloader.figshare.com/files/34427294 https://ndownloader.figshare.com/files/34427297 https://ndownloader.figshare.com/files/34427300 Murdan, Sudax Sudax Murdan Phuoc, Nguyen Ngoc Nguyen Ngoc Phuoc Basit, Abdul Abdul Basit N. Zadoks, Ruth Ruth N. Zadoks Herath, Tharangani Tharangani Herath 0000-0003-3367-9294 Bashir, Shazia Shazia Bashir 0000-0002-6756-9109 <![CDATA[An oral pH-responsive Streptococcus agalactiae vaccine formulation provides protective immunity to pathogen challenge in tilapia]]> Veterinary sciences not elsewhere classified vaccine, tilapia, fish, streptococcosis, microparticles, Eudragit E100, oral Group B Streptococcus Infections vaccine tilapia cage farms fish abundance Streptococcus agalactiae Isolates Circulating microparticle system Oral Veterinary Sciences not elsewhere classified 2022-10-26 2022-10-26 Dataset 2022 University College London Data related to the Table and figures in the publication (in title)

  

Table 1 shows Particle size measured by dynamic light scattering (mean±SD), n= 12 


Figure 5 shows   the Change in particle size (measured by dynamic light scattering) upon exposure to 0.1M HCl, which is simulating the acidic environment in a fasted tilapia stomach. Means are shown. Error bars reflect the SD. N=12


  

Fig 6 shows the pH measured in the different sections of the gastro- intestinal tract of fasted and fed tilapia (mean ± SD), N=5


  

Fig. 7 Shows the Cumulative percentage mortality in the 3 groups following oral gavage with: (ai) PBS in the negative control group; (aii) Blank Eudragit microparticles; (b) GBS-loaded Eudragit microparticles, and challenge by immersion using a homologous strain of Streptococus agalatiae sequence type on day 21 post-gavage. Error bars represent SD from 4 replicate tanks (25 fish per tank) for each of 3 treatment groups.


The data are shown in Excel files.  Data was collected using dynamic light scattering (Table 1, Figure 5), by measuring pH using a probe (Figure 6), and by counting the numbers of fish which survived the pathogen challenge with time. 



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