2026-10-15T08:42:44Z https://api.figshare.com/v2/oai

oai:figshare.com:article/19145783 2022-02-10T09:48:35Z category_27241 category_24721 category_24778 portal_753 item_type_3 month_year_02_2022

Angiogenic, apoptotic and autophagic profiling of chronic myeloid leukaemia patients’ platelets ex vivo before and after treatment with Imatinib Lisa Repsold (12064976) Annie Margaretha Joubert (108722) Gregory R. Tintinger (547003) Other health sciences not elsewhere classified Medical physiology not elsewhere classified Cancer cell biology Platelets Apoptosis Angiogenesis Autophagy Ex vivo Imatinib Chronic myeloid leukemia <p>The data presented here was to determine the angiogenic, apoptotic, and autophagic profiles of chronic myeloid leukaemia patients <i>ex vivo</i> on platelets before and after treatment with Imatinib. Platelet counts, viability and activation were determined by human cluster of differentiation (CD) 41 and -62 markers. The possible occurrence of apoptosis and autophagy was measured by means of flow cytometry and western blot analysis via Annexin V-fluorescein isothiocyanate (FITC), caspase 3, autophagy related gene 5 (Atg5) and light chain I and II (LC3) markers. Angiogenesis expression was determined through vascular endothelial growth factor (VEGF) and transforming growth factor β (TGFβ) markers.</p> 2022-02-10T09:48:35Z Dataset Dataset 10.25403/UPresearchdata.19145783.v1 https://figshare.com/articles/dataset/Angiogenic_apoptotic_and_autophagic_profiling_of_chronic_myeloid_leukaemia_patients_platelets_ex_vivo_before_and_after_treatment_with_Imatinib/19145783 CC BY 4.0