2026-10-13T03:23:22Z https://api.figshare.com/v2/oai

oai:figshare.com:article/17429456 2026-09-30T12:00:00Z category_33089 portal_2 item_type_8 month_year_09_2026

Microfluidic production of drug-loaded biodegradable polymer microparticles for targeted drug delivery Tymele Deydier (4499461) Chemical engineering not elsewhere classified microparticles Drug Delivery Applications encapsulation polymers biodegradable drug release emulsions microfluidics Chemical Engineering not elsewhere classified <p dir="ltr">In recent years, most of the new Active Pharmaceutical Ingredients (APIs) developed (e.g. Brolucizumab for macular degeneration, Romosozumab for steoporosis in postmenopausal women and Luspatercept for anemia) had either a low water solubility or a low membrane permeability (i.e. the ability to cross a biological membrane) which compromised both their bioavailability (i.e. the fraction of the drug from the initial administrated dosage that reaches the systemic circulatory system) and overall efficiency. Because these new drugs are often more potent than those currently on the market and have the potential to save and/or improve the lives of a large number of people, much research has been done over the past 30 years to develop new Drug Delivery Systems (DDSs) that can overcome their solubility and permeability limitations.Biodegradable polymer microparticles are one such DDSs that have received a lot of attention due to their biocompatibility and tailorable size, morphology and degradation rate. Microfluidics has become a promising field for the production of drug-loaded polymer microparticles as it enables the fabrication of particles of controllable size and high uniformity. Microfluidic particle production is achieved in two steps. First, uniform oil-in-water or water-in-oil droplets are generated with a microfluidic device. Then, the droplets are dried into solid particles using miscibility-based, pressure-controlled and/or temperature-controlled techniques.This thesis demonstrates the suitability of glass microfluidic devices for encapsulating drugs with low water solubility in polymer microparticles with encapsulation efficiencies between 50 and 90%. The scalability of the drug-loaded polymer microparticles production was also investigated.</p> 2022-07-05T15:19:18Z Text Thesis 10.26174/thesis.lboro.17429456.v1 https://figshare.com/articles/thesis/Microfluidic_production_of_drug-loaded_biodegradable_polymer_microparticles_for_targeted_drug_delivery/17429456 CC BY-NC-ND 4.0