2026-05-15T16:29:19Z https://api.figshare.com/v2/oai
oai:figshare.com:article/16573640 2021-09-14T12:42:40Z category_24811 portal_549 item_type_3 month_year_09_2021
10.5522/04/16573640.v1 https://figshare.com/articles/dataset/Multi-region_scRNA_and_scTCR_data_on_ADAPTeR_patient_cohort/16573640 https://ndownloader.figshare.com/files/30701183 https://ndownloader.figshare.com/files/30665975 10.2139/ssrn.3813274 Beattie, Gordon Gordon Beattie Au, Lewis Lewis Au Hatipoglu, Emine Emine Hatipoglu Robert De Massy, Marc Marc Robert De Massy Litchfield, Kevin Kevin Litchfield Schnidrig, Desiree Desiree Schnidrig Thompson, Rachael Rachael Thompson Byrne, Fiona Fiona Byrne Horswell, Stuart Stuart Horswell Fotiadis, Nicos Nicos Fotiadis Hazell, Steve Steve Hazell Nicol, David David Nicol Shepherd, Scott Scott Shepherd Fendler, Annika Annika Fendler Mason, Robert Robert Mason Del Rosario, Lyra Lyra Del Rosario Edmonds, Kim Kim Edmonds Lingard, Karla Karla Lingard Sarker, Sarah Sarah Sarker Mangwende, Mary Mary Mangwende Carlyle, Eleanor Eleanor Carlyle Attig, Jan Jan Attig Joshi, Kroopa Kroopa Joshi Uddin, Imran Imran Uddin D. Becker, Pablo Pablo D. Becker Werner Sunderland, Mariana Mariana Werner Sunderland Akarca, Ayse Ayse Akarca Puccio, Ignazio Ignazio Puccio Yang, William William Yang Lund, Tom Tom Lund Dhillon, Kim Kim Dhillon Vasquez Duran, Marcos Marcos Vasquez Duran Ghorani, Ehsan Ehsan Ghorani Xu, Hang Hang Xu Spencer, Charlotte Charlotte Spencer Lopez, Jose Jose Lopez Green, Anna Anna Green Mahedeva, Ula Ula Mahedeva Borg, Elaine Elaine Borg Mitchison, Miriam Miriam Mitchison Moore, David David Moore Proctor, Ian Ian Proctor Falzon, Mary Mary Falzon Pickering, Lisa Lisa Pickering Furness, Andrew Andrew Furness Reading, James James Reading Salgado, Roberto Roberto Salgado Marafioti, Teresa Teresa Marafioti Jamal-Hanjani, Mariam Mariam Jamal-Hanjani Kassiotis, George George Kassiotis Larkin, James James Larkin Swanton, Charles Charles Swanton Chain, Benny Benny Chain Quezada, Sergio Sergio Quezada Turajlic, Samra Samra Turajlic <![CDATA[Multi-region scRNA and scTCR data on ADAPTeR patient cohort]]> Oncology and carcinogenesis not elsewhere classified ADAPTeR scRNA scTCR Single Cell Renal cell carcinoma anti-PD-1 Cancer 2021-09-14 2023-05-31 Dataset 2021 University College London Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma'

Samples: Tumour infiltrating lymphocyes taken from two ccRCC patients post anti-PD-1 (nivolumab) treatment. One responder patient, one non-responder patient. For each patient cells were split by IgG4 binding (IgG4 = proxy for nivolumab binding), followed by 10x paired scRNA and scTCR sequencing.

Data analysis: sequencing files were demultiplexed and mapped to the hg38 genome and VDJ reference using cellranger count and cellranger vdj respectively. Expression matrices and VDJ annotations are provided in this submission. Also provided is cell metadata containing UMAP co-ordinates and other information pertinent to this study.

Files types: .mtx, .tsv, .csv

FIle size (compressed) 183.5MB
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