2026-05-09T06:08:06Z https://api.figshare.com/v2/oai

oai:figshare.com:article/14207687 2021-03-12T15:55:15Z category_27073 category_27091 category_24469 category_27133 portal_549 item_type_23 month_year_03_2021

10.5522/04/14207687.v1 https://figshare.com/articles/data_management_plan/Incidence_of_COPD_and_quality_of_subsequent_treatment_among_people_with_a_history_of_using_illicit_opioids_a_cohort_study_in_England_PROTOCOL_/14207687 https://ndownloader.figshare.com/files/26798129 10.12688/wellcomeopenres.16431.1 Lewer, Dan Dan Lewer Denaxas, Spiros Spiros Denaxas Gonzalez-Izquierdo, Arturo Arturo Gonzalez-Izquierdo Zaninotto, Paola Paola Zaninotto Qummer Ul Arfeen, Muhammad Muhammad Qummer Ul Arfeen D. Brothers, Thomas Thomas D. Brothers Padmanathan, Prianka Prianka Padmanathan 0000-0003-1292-6575 K. Quint, Jennifer Jennifer K. Quint Epidemiology not elsewhere classified Health and community services Respiratory diseases Primary health care Public Health Substance Use Disorders Opioids Respiratory Diseases Chronic Obstructive Pulmonary Disease COPD COPD exacerbation Primary care Epidemiology Health and Community Services Respiratory Diseases Primary Health Care 2021-03-12 2023-05-31 Data management plan 2021 University College London Chronic obstructive pulmonary disease (COPD) is common among people who use illicit opioids. This study will estimate the incidence of diagnosed COPD and the rate of death due to COPD among patients in primary care in England with previous records of illicit opioid use, and compare this to patients without records of illicit opioid use. Among patients with a new COPD diagnosis, we estimate the association between illicit opioid use and the probability of preventative healthcare such as flu and pneumococcal vaccines or support with smoking cessation, and the association between illicit opioid use and adverse outcomes such as acute exacerbations and death. Data will be drawn from the Clinical Practice Research Datalink (CPRD), using a validated method to identify patients with a history of illicit opioid use. Patients without a history of illicit opioid use will be selected using a process called ‘exposure density sampling’ to create a cohort matched on age, sex, GP practice, and date of cohort entry.

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