These data contain activity (in form of calcium traces) of single retinal axon terminals (boutons) imaged in the superior colliculus of mouse. Mice were able to run on a floating ball. Running speed and pupil size were recorded simultaneously. Mice were presented with full-field, drifting, sinusoidal gratings (“gratings”), uniform gray screens (“grayScreen”), darkness (“dark”), or black and white squares on gray background (“noise”). See Schröder et al. (2020) for details on methods.